The second season of Formula 1 begins and the first race is in Switzerland and it had 21 racers. All but one of the Alfa Romeo's drivers fully remained the one being Fagioli. This was due to him being too old to drive, he would however stick in some more races of the year. Replacing his position as the team's third driver, was their long-time test driver, Consalvo Sanesi. The Scuderia Ferrari, had a serious chance of taking the world title for 1951. The 375 had proven extremely competitive. However, Ferrari was the worst one in the preparation, this begins with the lead driver Alberto Ascari burning his hand following a Formula Two accident in Genoa. Peter Whitehead would also continue to compete in his privately owned Ferrari 125. However the old 125 was quickly becoming out of date and would not be capable of competing with the Alfa Romeo 159 or the Ferrari 375. The Talbot Lago would not participate after humiliated at the Reims-Gueux although another car would still be listed. This would also happen to The Maserati, however, it wouldn't be listed. Simca Gordini also decided to withdraw from the event. Sadly, the weather of the rain was not very good and had caused many incidents and dangerous moments especially a broken leg from a dangerous car by Louveau's car and had made Whitehead crash in the same place. After that, it was straight forward. In the end, the race was won by Juan Manuel Fangio with a time of 2:07:53.64 and the last one was Guy Mariesse.

The second race was the second official Indianapolis 500 race and had 33 racers. This was the safest Indianapolis in history, however, only eight racers finished. One of the drivers is Joe James who retired due to transmission issues. Johnny McDowell would not be far behind after he ruptured his fuel tank in the pits on the fifteenth lap. And then three laps later, Mack Hellings pulls off into the pits because of damage to his engine. One of the more dangerous but not brutal moments was done by Mauri Rose who accidentally skid and flipped his car. The winner was Lee Wallard with a time of 3:57:38.05.

The third race was in Belgium and had 16 racers. One surprising fact about this race, was that the racers leaderboard would be much smaller than before, leaving out the Maserati and the Enrico Platé, Alfa Romeo would also decide to keep it's three main drivers and have Fangio race the car with the triple fuel tank. Fangio's start had been terrible, he dropped to fifth place behind Villoresi, Farina, Ascari and Sanesi. Étancelin had failed to make it off the start-line, his Talbot-Lago failing with transmission problems. Fangio would then have a fight with Ferrari and Villoresi but he would win it and would manage to keep a good race after that. However, Fangio would have the opposite. In the pit stop, the mechanics had realized that his car would not be able to start again due to a stuck hub and would take a long time to fix. Fangio remained cool throughout the pit stop, his frustrations appearing to not show through his character. Fangio took to the race track in last place. In the end, the race was won by Nino Farina with a time of 2:45:46.2.

The fourth race was set in France and had 23 racers. The powerful Alfa Romeo's were expected to run well on this circuit, however the more fuel conservative Ferrari's still had a good chance in the race. After Ferrari had three hard times bad luck with the Alfa Romeo, Ferrari knew that they were their biggest target. Fangio sat only two points behind Farina and was determined not to lose out to him in France. Alberto Ascari sat third in the championship with six points. He remained six points adrift of championship leader Farina, yet hoped to close the gap in France. In the beginning of the race, Fangio was immediately taken over by Ferrari and Ascari. The Reims circuit was notorious for breaking cars, and after only a single lap, Whitehead had retired with a blown engine. De Graffenried also retired his Maserati with engine problems. Marimón's first race in the Milano engined Maserati also came to an end after two laps when his Milano blew up. Manzon who had been having an underwhelming weekend was also out on lap three with engine troubles. Simon in a second Simca-Gordini car then blew its engine on lap seven. Fangio had a close fight with Ferrari and Villoresi which was problematic when began to develop a misfire problem, forcing him into an early pit stop so his mechanics could check the car. The problem continued and was a struggle for the race. However, they managed to win together after Ascari's car broke and Ferrari could not surpass them. The race was then won by Luigi Fagioli and Juan Manuel Fangio with a time of 3" 22' 11.0.

The fifth race was set in Britain and contained 20 racers. For a first time ever, Alfa Romeo would not only keep the three main drivers but would also create a fourth car for Luigi Fagioli, however, after selling the car away, he decided to quit. Bonetto, the former man to head the Milano project would take over Fagioli's contract to run the remaining races of the season for Alfa Romeo as a fourth car. The Ferrari had felt that they were getting to the power of the Alfa Romeo apart from a few problems in the 375 chassis. A new car had also come into play which was the the BRM, ( with reluctant choice from Raymond Mays, team founder and Peter Berthon due to it feeling incomplete ). At the beginning, Bonetto would manage to leave seventh place and manage to surpass the Alfa Romeo to the Villoresi leading the BRM to a too good to be true start. Which would be the case after Bonetto fell to fifth and on lap 15, Villoresi failed a maneuver on Bonetto at Copse and spun. By the time Villoresi rejoined, the final Alfa Romeo of Sanesi had taken sixth place. The Alfa Romeo would be again faced with the Ferrari and Ascari fight which lead to them being outpaced by Ferrari and even more in trouble during their pit stop and Farina breaking down with clutch failure allowing Villoresi to move into fourth position. In the end, the race was won by José Froilán González with a time of 2" 42' 18.2.

The sixth race was in Germany and had 22 racers. After winning multiple races and feeling the best of the best last season, the team of Ferrari had finally caught up to the Alfa Romeo in Silverstone making them the non number one. This had made Giuseppe Farina mad and had started some discussions about him leaving the team. After a diminished representation in Silverstone, the Talbot-Lago's were once again the major representation of the field in Germany. In the race, Farina got a perfect start and took the lead ahead of Fangio, Ascari and González. However before the end of the first lap, all three drivers had made their way past Farina and the champion fell back into his starting position. However, Ascari lost the lead and all apart from Farina went to their pits, Farina's car had retired with with overheating trouble. Fangio would then take lead after Ferrari and Ascari went to their pit stops and before he realized it, Fangio was the only Alfa Romeo left alive in the race. It would be problematic when Ascari would surpass Fangio after his pit stop due to a gearbox problem, the Ferrari lead man had taken control. However on lap 17 he began to develop a slow puncture, there was fear that once again Ascari would be denied a race win. However Ascari's lead was so large that even in losing time in an unscheduled pit-stop, he maintained the lead to Fangio in second place. And in fact, Ferrari would win the race again, specifically, Alberto Ascari with a time of 3" 23' 03.3.

The penultimate race of the season was in Italy and had 23 racers. Alfa Romeo fielded four drivers for their home event. Fangio looked set to take his first title for Alfa Romeo whilst the reigning champion, Giuseppe Farina had still a faint hope of reclaiming his title distanced after an unreliable season. Felice Bonetto and Consalvo Sanesi were called in to occupy the third and fourth Alfa Romeo cars. Due to the Ferrari wanting to stay ahead from the Alfa Romeo, they created seven cars, ( their highest amount ). Immediately in the race, the already broken BRM felt even more broken, leading them to withdraw from the race. In this race, Ferrari was the one having a bad start but Ascari knew they could catch up. On lap five, Farina began to drop back due to an engine misfire. After dropping to last place, Farina decided to come into the pits for repairs on lap eight. However the mechanics found a terminal oil system problem, forcing the world champion out of the race. Fangio would then get to fourth place and would start pushing hard for the win, he would also be their only hope at beating Ferrari. Sadly, Fangio would experience a engine cut whilst exiting the Parabolica. He coasted into the pits where the mechanics quickly discovered a cracked fuel tank. The hope was lost and Ferrari won again, specifically, Alberto Ascari with a time of 2" 42' 39.3.

The final race of the season was set in Spain and had a total of 20 racers. With the Ferrari having managed to outsmart Alfa Romeo twice in a row, it looked like the battle was going to be pretty intense and exciting. Just like sixth, the Ferrari had a good start while the Romeo had a bad start, but to return to the favor of Fangio, on the second lap González spun, dropping behind Farina, Fangio, Bonetto and Villoresi. On the third lap, Fangio moved past his teammate Farina whilst on the fourth, race leader Ascari was passed by Fangio's Alfa Romeo. However, the fight was still on. The Ferrari's began to encounter severe Tyre degradation, all their cars would be required to make a pit-stop. Taruffi pitted on lap 6, Villoresi on lap 8, Ascari on lap 9 and González on lap 14. The Alfa Romeo had the best luck they could have wished you, running with no problems and Ferrari having the opposite, which led the Alfa Romeo to win the 1951 world cup. The winner was Juan Manuel Fangio with a time of 2" 46' 54.10.