Maja needs weight-loss surgery so she can lose weight. Dr. Now won't approve her for surgery if she can't overcome getting dumped by her boyfriend without using food to cope. Justin charts a course to be one of Dr. Now's best patients ever.

There is much to be gained and lost for Brianne in year two of her journey, in which she both loses weight and gains independence. Getting back with Erica becomes the top priority for Annjeanette, who chooses love over even her own health.

Right when Angie starts to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos. Angie moves ahead despite dire difficulties, but when her body starts to break down, Angie fears the worst...and faces it alone.

Angie enters the most trying stretch of her weight-loss journey; she finds herself on the brink of homelessness after Dr. Now refuses to keep her in his program unless she submits to drug rehab for substance abuse.

Jeanne struggles to care for herself in the aftermath of her dad's death. Brandon strives to get his weight down in order to feel confident when proposing to his girlfriend Tayler and be the man she deserves.

Cillas must face difficulties from his childhood to progress to his goal weight and set an example for his children. Tiffany struggles to lose weight when financial hardships place a strain on her relationship with her boyfriend, Aaron.