Melissa finds herself overwhelmed with four children, a marriage on the rocks, and an unexpected pregnancy. When Ashley's weight loss journey hits a wall, she sets out to find new inspiration to get herself back on track towards a healthy lifestyle.

Christina's weight loss has gone too far, too fast, and now threatens her life. After losing 300 lbs, Paula must endure more surgery to deal with a body entirely covered in loose and sagging excess skin.

Zsalynn is excited for a fresh start but her 360-body lift at a Beverly Hills clinic proves more challenging than expected. Lonely and depressed since her gastric surgery, Olivia wants skin removal surgery but struggles to lose the weight to qualify.

Betti Jo battles depression and a cancer diagnosis and when she finds out she's pregnant, she and her husband must find a way to cope. Susan suffers a major setback after surgery for her excess skin, thwarting her hopes to conquer her obesity.

Joe has come a long way from being morbidly obese: He's in love and contemplating proposing to his girlfriend. Just when life holds so much promise, his mom has few health scares and forces Joe to balance his new love with his mother's health crisis.

Despite having lost 378 lbs, Angela's knee pain combined with a history of obesity threatens everything she's worked for. Charity must find the strength to return to her goals of getting healthy.

Laura has lost 300 lbs + and is much less dependent on her husband Joey, who is now having trouble finding his way in the relationship. Marla, one of Dr. Now's most challenging patients returns and the fireworks begin all over again.

Pauline must find the will to keep up her weight-loss progress after a medical emergency. Chay's finally admitting what he's long known, that he's a transgender woman. But, the emotional stress of coming out could threaten his weight loss journey.