Dr. Nowzaradan is worried Lupe's emotional issues are blocking her weight loss journey since she's shed over 300 lbs but still can't walk. When Ashley is struck with sudden paralysis, her own emotional stability is thrown into peril.

Gastric surgery freed Brittani from her housebound life, but to achieve her ideal body she'll have to endure two more painful surgeries. Sean's super-obesity nearly killed him...Will he finally make a break from his mother's over-protective care?

Surgery enables Teretha to finally return to family in Detroit but it soon threatens to undo all the progress she's made. After his weight loss surgery, trucker Chad gets back on the road, but the job is putting any further weight loss in peril.

After losing 250 lbs, Nikki is on her way to skin surgery that will transform her body. But when a close friend dies from weight loss surgery, Nikki's progress goes off track, derailed by fears of another surgery and if she'll make it out alive.

Devastated by the sudden loss of her son, Dottie's weight loss journey is in danger of going off track. After her gastric bypass surgery, June embarks on a plan to win approval for skin surgery and start living the life she always dreamed of having.

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Charity managed to lose over 400 pounds, but now her daughter Charly is becoming dangerously obese. Can Charity help her avoid the same fate? Devastated by the death of her husband Elroy, Milla must find a way to finally qualify for gastric bypass.

Joe was once 800 lbs, housebound and alone. Now engaged and planning a wedding, can he continue his weight loss? After losing over 300 lbs, Pauline is on the verge of independence if only she can qualify for the skin surgery she needs so badly.

Surgery enabled Laura's independence but the complications nearly killed her and she's terrified about the skin surgery. Chay revealed to her family she was transgender but living life as an overweight woman; can she stick to her weight loss journey?