4x1 – Die liebe Schwiegermutter
When Melanie's mother comes for a surprise visit, Trapper learns that Melanie has kept their divorce a secret from her for the last six years. Gonzo suggests that a doctor should work as a nurse for a week to get a better idea of the problems they are having, and he gets volunteered for the job.
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4x2 – Waffen statt Wein
Trapper John and Gonzo discover the vineyard they bought was a scam, finding both infertile soil and evidence of criminal behavior in a basement.
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4x3 – Wo bleibt der Trauzeuge?
Trapper John and Gonzo are captured while at their vineyard. A representative for survivors of nuclear radiation exposure tries to get help from San Francisco Memorial.
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4x4 – Für was ist der Doktor da?
Trapper falls for a hospital scrubwoman, while Slocum falls for a patient.
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4x5 – Hellseherin und Simulant
Jackpot recommends surgery for a man who suffers from Munchausen syndrome, a psychological disorder which leads him to fake symptoms.
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4x6 – Pfennigfuchser und Nackedeis
A miserly industrialist with an obsession for anonymity badgers the hospital staff.
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4x7 – Ein hoher Preis
A bitter former hospital employee takes Riverside hostage and demands $1 million ransom.
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4x8 – Erntedankfest
On a foggy Thanksgiving, Slocum hits Trapper with his car. As John fights for his life, staff members recall (in flashbacks) reasons they have to be thankful for his friendship and help.
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4x9 – Der ideale Urlaub
Gonzo and Shoop send Trapper on vacation to Geneva Springs. While Trapper substitutes for a small-town doctor, Riverside is fired and a former patient of Trapper's needs heart surgery.
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4x10 – Ein talentierter Kollege
Talented neurosurgeon Russ Brandis enduring a deadly disease and fits of rage he shows are due to the drugs he must take. The surgeon's personal problems are uncovered as Riverside and Gonzo try to recruit him for the hospital staff.
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4x11 – Ein diplomatischer Patient
A Soviet diplomat is admitted with pain from a liver tumor.
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4x12 – Die grausame Wahrheit
Vinnie Duncan, Gonzo's good friend, leads a fund campaign for rare-disease drugs.
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4x13 – Der Junge ist ein Mädchen
A baby admitted to the hospital for a urinary tract infection turns out to be a hermaphrodite, sparking a battle between the parents over which sex it should be.
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4x14 – Ein schwieriges Kind
When Gloria Brancusi learns that Andrea, the orphan girl, has come back to the hospital as a patient her first reaction is to run away. Gloria has second thoughts after deciding to adopt the troubled orphan.
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4x15 – Die Schwester hat ein Problem
An emotionally troubled musician is released much too early from the hospital. Nurse Shoop suffers a hearing loss.
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4x16 – Unheilbar krank
A brilliant surgeon begins suffering from bouts of forgetful and disoriented behavior.
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4x17 – Ein Kunstfehler
Gonzo's professional confidence and bedside manner are affected by a malpractice lawsuit, after a young patient asserts that he has begun to feel worse after an emergency operation. A patient is mistaken for a hospital inspector.
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4x18 – Eine Jugendsünde taucht auf
A woman from Riverside's past is obsessed with him.
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4x19 – Synthetische Viren
Gonzo's mother introduces him to her new boyfriend, a sportswriter his age. Gonzo is not happy about the situation.
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4x20 – Mutter auf Abwegen
Trapper fears an epidemic after the leader of a research project becomes mysteriously ill.
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4x21 – Freundschaft bedroht
When Gonzo starts dating a high society woman she tries to convince set up his own private practice and into selling the "Titanic" to Jackpot.
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4x22 – Aus eigener Kraft
Gonzo rescues a woman who was injured on some broken stairs inside a rundown apartment building. After he traces the ownership of said building to SFM, the board decides that the best solution is to tear down the building and build condos in its place.
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