A bag full of evidence recovered from an iced-over river helps to reveal the murderer of a businesswoman in her own shop.

A successful and well-liked real estate agent is brutally murdered in a model home. Can the police find out who did it?

Two teen boys murders one of the boys father in the winter in Minnesota.

After a politician dies of an apparent heart attack, an observant medical aide suspects poisoning and takes blood and urine samples. They become crucial evidence when investigators learn of incriminating remarks made by a suspect.

A U.S. Navy air traffic controller is found raped and murdered in her own home, and the body of one of her male co-workers is found right next to her bed. Is this crime the result of workplace sexual harassment and rape?

A man is found stabbed to death after a night in a strip club. A drop of blood on a bedspread becomes critical evidence five yeas later.

The body of an exotic is found underneath a bridge in New Jersey. It appears that she had committed suicide by jumping to her death, until police discover evidence of murder.

A construction foreman's murder is solved when an investigator notices some unusual characteristics of a few drops of blood.

In 2000, Judy Southern came home from work and was shot by a gunman waiting for her. Her husband Allen arrived afterwards, called 911 and drove her to the hospital. She died on arrival and the investigation focused on her husband Allen, but forensic analysis and a suicide note found at the scene pointed to someone else. Originally aired as Season 13, Episode 9.

A woman's story seemed far fetched: A man wearing only underwear and gloves broke into the house, stabbed her boyfriend to death, and raped and terrorized her for hours afterward. But the evidence at the scene supported her story, and investigators turned for help to the FBI and their criminal profilers.

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Suspected in the murder of his mother, a Delaware man tries to convince detectives that the real killer is a hitchhiker he had picked up.

Ginger Hayes and her infant son Nicholas were abducted during a carjacking and the crime had been reported by a witness within minutes of occurrence. The witness pointed to Andre Edwards as the culprit. When Ginger and Nicholas were found, Ginger had been beaten to death, but Nicholas was still alive. Originally aired as Season 13, Episode 12.

A college student is abducted and murdered five days before Christmas. Eight years pass before a cell phone and a pair of running shoes implicates a suspect.

A North Carolina woman is raped and strangled in her apartment. Authorities are unable to link the prime suspect to the homicide, until they discover a connection to an unsolved Michigan murder that was committed a few years earlier.

Blood spatters at a suspect's house reveal the identity of the victim, the murderer, and the weapon used to commit the crime.

Police pursue a masked serial rapist who is terrorizing a Texas community.

The victim has been stabbed more than thirty times, and the crime scene is awash with her blood. Near her head, police discover a distinctive button with strands of thread still attached. If they can find the owner of the shirt the button came from, they'll also find the killer. Originally aired as Season 13, Episode 17.

A young woman heads home after church, but never makes it there alive. Police learn that car trouble lead the victim to accept help from someone she thought was a Good Samaritan. But when the search for suspects and forensic science points to employees from other churches investigators learn that looks truly are deceiving.

When a nine-year-old girl goes missing, police and volunteers spend weeks searching for her. A psychic's vision leads to a field where her body is discovered, along with what investigators hope is enough evidence to help them to also find her killer. Originally aired as Season 13, Episode 19.

Digital enhancement of security camera video shows that what appears to be a casual encounter is actually a forced abduction, leading to murder. The perpetrator's MO is remarkably similar to another murder which occurred five months earlier, 15 miles away. When investigators learn the crimes might not be isolated or random, they also realize a serial killer may be on the loose.

A sadistic serial rapist runs rampant through Delaware and Maryland. One woman had been sexually assaulted, stabbed repeatedly, and left for dead. Brenda Robinson survived, and gave police a detailed description of her attacker. When someone who fit that description practically turned himself in, police were sure they had their man. Originally aired as Season 13, Episode 21.

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The murder of a Kentucky businessman appears to have been the work of an intruder. But when police discover racy photos, they suspect the victim knew his killer.

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A medical examiner is suspicious when a drowning victim's brain shows signs of an attack hours before death. A computer analysis and paint on a shoe reveal the murderer's identity.

Two friends out on the town see a red truck drive by with a woman screaming in the back. Later, their friend is reported missing, and her body is found in a nearby river.

A court official and his wife are attacked in their sleep by an ax-wielding murderer. Is the killer a member of 'the family'?

Two suspects living together were linked to a murder by bloodstained boots and a gun, items that belonged to the man who said he'd never met the victim. Investigators hoped the manufacturing code on beer bottles would determine who was telling the truth. Originally aired as Season 13, Episode 26.

A string of church bombings rocks an Eastern Illinois community and police quickly apprehend the people responsible. But investigators are baffled when the bombings continue, and have no choice but to reopen the case. A rare type of wire, a rhinestone dog collar and a hypnotist help detectives finally close the book on an explosive investigation

There was no clear reason for a young, healthy college student to be dead. But when the medical examiner discovered the tiniest of clues during the autopsy, investigators were able to uncover the mystery filled with betrayal and revenge. Originally aired on August 28, 2009. Season 13, Episode 28.

A young woman is stabbed more than 100 times. The killer leaves DNA behind, but investigators must play a cat-and-mouse game trying to obtain a suspect's DNA to match. Will he make a mistake?

On Christmas Eve, the corpse of a black male was found burning near Baltimore. He was eventually identified as twenty-six year-old Wesley Person. Distinctive building materials from the 1930s found near the body played a critical role in solving this puzzling case. Originally aired as Season 13, Episode 30.

Doctors don't know why the young scientist is gravely ill. When tests finally reveal the cause, it's too late to save him. Police hope that lab analysis of his hair, showing when attempts were made on his life and what was used, will lead to the killer. Originally aired as Season 13, Episode 31.

A bullet-riddled car is discovered under a California freeway and the driver, a twenty-year-old woman, is found dead a month later. Red glitter leads police to her killer.

Workers discovered a teenage girl's half-naked body on the side of the road; her throat had been slit. Police hoped the single foreign hair found in a defensive wound on her thumb would lead them to the culprit. Originally aired as Season 13, Episode 33.

A woman is found dead in the rubble of her burned Seattle apartment. The body another woman is later found in the same apartment complex under similar circumstances, leading authorities to believe the two homicides are connected.

When a college co-ed disappeared without a trace, her fellow students were concerned about her safety and their own. Weeks later, the body of an unknown female was found hundreds of miles away in the ashes of a barn fire, and an alert police officer was convinced the two crimes might be connected. Originally aired as Season 13, Episode 35.

When a woman is found murdered in her Florida home, her former boyfriend's name is discovered written in blood on a nearby wall. Detectives must determine whether it was written by the victim to name her killer, or by the killer as a ruse.

A manager of a Florida restaurant is stabbed to death and the motive appears to be robbery. Blood drops near the sink and fingerprints on a folder are the clues to solving the crime.

While working the night shift at a Florida convenience store, a woman was abducted, raped, and murdered. Nearly two decades later, a reexamination of the case revealed DNA on the victim's socks.

When a man's body is found burned in a parking lot, investigators use tire track impressions and security camera video to find the killer.

A respected surgeon was stabbed to death in the parking lot next to his office. The most likely suspect is seen having dinner in a restaurant at the time of the murder. But a cryptic conversation leads police to believe that, while the suspect may not have wielded the knife, he could very well have hired the man who did. Originally aired as Season 13, Episode 40.

A young couple is found murdered in their Graham, Washington home; detectives discover shoe impressions, a partial palm print, and a neighbor's criminal past.

Terrified, the young girl hid in her bedroom while her mother was attacked and stabbed to death. Investigators had a wealth of evidence: shoe impressions, distinctive blood drops, and the killer's DNA. What they didn't have was a basis for comparison. Originally aired as Season 13, Episode 41.

The gunman opened fire as the family of four entered their home, killing two and wounding the others. He'd pulled open a few drawers to make it look like a robbery, but the scene was clearly staged. When police pieced together the clues, they discovered an unlikely suspect and a carefully orchestrated plot. Originally aired as Season 13, Episode 42.

In Newport Beach, California, a woman is fatally stabbed and her body is found in the harbor near a yacht club. Suspecting it was a rage killing, police investigate the victim's daughter and ex-husband.

A Minnesota state park employee is murdered and a wristwatch is discovered at the crime scene, leading investigators to believe it belonged to her killer.

A Texas factory worker disappears, but her family does not believe it was voluntary.

A couple goes on a trip to Ocean City, Maryland, where they encounter another couple and disappear.

A Texas housewife is murdered and her young daughter is attacked but survives. An in-law is suspected, but no arrests are made until DNA advancements help crack the case 15 years later.

A woman is bound with electrical cords from a reptile tank heated rock, and murdered. Investigators are able to match forensic evidence to the owner of a boa constrictor living nearby.

Shamaia Smith disappeared from the strip club where she worked in East Hartford, CT. Police focus on local businessman Kenneth Otto when there are inconsistencies with his story. Otto's property is searched and cadaver dogs find something in a fire pit. Originally aired as Season 13, Episode 50.