6x1 – Neues Team, neues Problem
The new team deal with incidents including a patient who dies following a routine liposuction procedure and a priest with a genital mutation.
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6x2 – Das geschundene Herz
Geiger and Waters argue over which patient is more deserving of a donor heart.
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6x3 – Viel Arbeit – So ein Mensch
A newborn's life is in the hands of a heart surgeon who has Tourette's Syndrome.
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6x4 – Aus Wachsamkeit und Fürsorge
Dr. McNeil puts the life of a young ballplayer in jeopardy while trying to save the boy's arm.
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6x5 – Die Tat eines Verzweifelten
The surgeons of Chicago Hope work together in an attempt to save the life of Dr. Cacaci.
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6x6 – Leben nach dem Tod
The widow of a heart attack victim wants to be impregnated with sperm from her husband's body but his parents object to the procedure. A young boy requires brain surgery to remove a tumour. Down in the basement, two medical transcribers plot to sell copies of a doctor's notes to a tabloid newspaper.
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6x7 – Weißes Kaninchen, schwarzer Tod
A killer virus sweeps through the hospital, killing everyone who catches it.
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6x8 – Organe für Robert
Dr. Alberghetti performs experimental lung surgery with help, via satellite and the internet, from a doctor in Sri Lanka. Dr. Geiger helps his daughter Alicia prepare for her Thanksgiving play.
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6x9 – Ein Tag wie nie zuvor
Jack & Aaron deal with shooting victims at a bookie joint in an old warehouse while the shooter keeps the police at bay. Drs. Alberghetti and Hanlon fight to save a woman who was brutally stabbed.
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6x10 – Dr. Hanlon hat die Wahl
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6x11 – Glaube, Hoffnung, Chirurgie
Dr. Simon performs brain surgery on a friend suffering from Parkinson's and then has to deal with the man's mother when things go wrong. Dr. Geiger deals with a doctor who is doing research into human cloning and with an elderly patient who is ready to die.
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6x12 – Die Beste ihres Faches
Keith's estranged aunt, Dr. Odelia Wilkes, is brought in to perform surgery on a tuberculosis patient. Dr. Simon struggles to diagnose a patient whose twin sister died from leukaemia.
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6x13 – Das Mädchen, das ein Junge war
Jack and Jeremy help a teenage girl who was born a boy. Gina and Francesca treat an elderly woman suffering from Alzheimer's.
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6x14 – Vielleicht wie durch ein Wunder doch
A father must choose which of his two dying children will get his liver donation. Dr. Rose Weber suffers a seizure at work. Aaron and Gina deal with their budding relationship.
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6x15 – Es sind ja nur Tests
At the same time his daughter Alicia needs heart surgery, Geiger is pressured by the board to make massive cuts to the hospital's budget. Conjoined twins arrive in the emergency room, one suffering a cut on his leg, the other needing an appendectomy.
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6x16 – Um der Gerechtigkeit willen
Gina helps a mentally challenged couple after discovering a surgeon at the hospital had sterilized the woman years earlier.
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6x17 – Todesengel im Fahrstuhl
A steroid using wrestler with a knee injury learns she may have cancer. Aaron and Gina come up with a plan to use hypothermia on a young girl to better her chances of surviving brain surgery. Keith's son Ray asks his dad for help with a sick tarantula.
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6x18 – Die siamesischen Zwillinge
An old friend of Jack's shows up in the ER with a minor gunshot wound and a major heart defect. The conjoined twins return to the hospital and when Jeremy discovers one of them has developed pancreatic cancer, she tries to convince them to have separation surgery.
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6x19 – Mister Miller und die Ärzte
Chicago Hope is bought by an HMO and new CEO Hugh Miller starts making cuts. A young couple learns their pregnancy is not progressing normally.
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6x20 – Gedankenlesen wird möglich
Gina and Aaron are given permission to perform experimental brain surgery on a paralyzed patient but Jack has to jump through hoops to be allowed to do a hip replacement on an ex-football player. Jeremy and Francesca discuss their feelings about new CEO Hugh Miller.
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6x21 – Jeder ist etwas Besonderes!
After suffering a medical emergency, Hugh experiences care at Chicago Hope firsthand. A woman who went into a coma giving birth reawakens after 15 years and is reunited with her husband and daughter. A man is being denied coverage for life saving heart surgery by his HMO who consider the procedure to be experimental.
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6x22 – Der Intelligenz-Chip – Die Rettung?
Hoyt Hospital Services wants to buy the hospital as an empty facility; Dr. Simon has an ectopic pregnancy; Dr. McNeill performs a miraculous surgery
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